2-amino-3-[tri(phenyl)methylthio]propionic acid
H-D-Cys(Trt)-OH
CAS: 25840-82-8
Molecular Formula: C22H21NO2S
2-amino-3-[tri(phenyl)methylthio]propionic acid - Names and Identifiers
2-amino-3-[tri(phenyl)methylthio]propionic acid - Physico-chemical Properties
| Molecular Formula | C22H21NO2S |
| Molar Mass | 363.47 |
| Density | 1.232±0.06 g/cm3(Predicted) |
| Boling Point | 524.7±50.0 °C(Predicted) |
| Flash Point | 271.2°C |
| Water Solubility | Sparingly soluble in water 0.022 g/L 25°C. |
| Appearance | Solid |
| pKa | 2.22±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
2-amino-3-[tri(phenyl)methylthio]propionic acid - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
2-amino-3-[tri(phenyl)methylthio]propionic acid - Introduction
H-D-Cys(Trt)-OH(H-D-Cys(Trt)-OH) is an organic compound with the following properties:
1. Appearance: H-D-Cys(Trt)-OH is a white crystalline powder.
2. Solubility: H-D-Cys(Trt)-OH is dissolved in some organic solvents, such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM).
3. Melting point: The melting point of H-D-Cys(Trt)-OH is between about 135-140°C.
The main use of H-D-Cys(Trt)-OH is as a protective group for synthetic peptides in the fields of biochemistry and medicinal chemistry. It protects the side chain of cystine (Cys) from unwanted side reactions during synthesis. At the same time, H-D-Cys(Trt)-OH can also be used as a precursor for the synthesis of compounds or drugs, and as a probe in the study of biological activity.
The preparation of H-D-Cys(Trt)-OH is usually obtained by chemical synthesis. A common synthetic method is to react benzyltrimethylsilylmalonic anhydride (Boc-Cys(Trt)-OH) with D-cysteine to give H-D-Cys(Trt)-OH. In the reaction, an amino protecting group (such as BOC) may be used to protect the amine group to prevent unwanted reactions.
For safety information, data on toxicity and harmfulness of H-D-Cys(Trt)-OH are currently limited. However, as a chemical reagent, it should follow normal laboratory practices and safe operating procedures. Appropriate personal protective equipment, such as lab gloves and protective glasses, should be worn. If aspiration or contact with skin, wash immediately and seek medical help.
1. Appearance: H-D-Cys(Trt)-OH is a white crystalline powder.
2. Solubility: H-D-Cys(Trt)-OH is dissolved in some organic solvents, such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM).
3. Melting point: The melting point of H-D-Cys(Trt)-OH is between about 135-140°C.
The main use of H-D-Cys(Trt)-OH is as a protective group for synthetic peptides in the fields of biochemistry and medicinal chemistry. It protects the side chain of cystine (Cys) from unwanted side reactions during synthesis. At the same time, H-D-Cys(Trt)-OH can also be used as a precursor for the synthesis of compounds or drugs, and as a probe in the study of biological activity.
The preparation of H-D-Cys(Trt)-OH is usually obtained by chemical synthesis. A common synthetic method is to react benzyltrimethylsilylmalonic anhydride (Boc-Cys(Trt)-OH) with D-cysteine to give H-D-Cys(Trt)-OH. In the reaction, an amino protecting group (such as BOC) may be used to protect the amine group to prevent unwanted reactions.
For safety information, data on toxicity and harmfulness of H-D-Cys(Trt)-OH are currently limited. However, as a chemical reagent, it should follow normal laboratory practices and safe operating procedures. Appropriate personal protective equipment, such as lab gloves and protective glasses, should be worn. If aspiration or contact with skin, wash immediately and seek medical help.
Last Update：2024-04-09 20:45:29
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